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Antimicrob. Agents Chemother., Oct 1997, 2289-2291, Vol 41, No. 10
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa

M Nakano, T Deguchi, T Kawamura, M Yasuda, M Kimura, Y Okano and Y Kawada
Department of Urology, Gifu University School of Medicine, Japan.

We determined partial sequences of the gyrA and parC genes of the fluoroquinolone-susceptible strain ATCC 27853 and 22 clinical isolates of Pseudomonas aeruginosa. While a single amino acid change in GyrA with or without a change in ParC was found in 14 isolates with decreased susceptibility to fluoroquinolones, 3 higher-level fluoroquinolone-resistant isolates had a double amino acid change in GyrA and a single amino acid change in ParC.

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