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Antimicrob. Agents Chemother., Oct 1997, 2295-2296, Vol 41, No. 10
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Low-level release of Shiga-like toxin (verocytotoxin) and endotoxin from enterohemorrhagic Escherichia coli treated with imipenem

K Takahashi, K Narita, Y Kato, T Sugiyama, N Koide, T Yoshida and T Yokochi
Department of Microbiology and Immunology, Aichi Medical University, Nagakute, Japan.

Shiga-like toxin (SLT) and endotoxin may participate in the pathogenesis of enterohemorrhagic Escherichia coli (EHEC) infection. Levels of release of SLT and endotoxin from EHEC treated in vitro with antibiotics were estimated. There were differential levels of release of SLT and endotoxin from EHEC treated with different antibiotics. Treatment of EHEC strains, namely, E. coli O157, O111, and O26, with imipenem induced much lower levels of release of SLT and endotoxin than treatment with ceftazidime.

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