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Antimicrobial Agents and Chemotherapy, 06 1997, 1349-1351, Vol 41, No. 6
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Modified agar dilution susceptibility testing method for determining in vitro activities of antifungal agents, including azole compounds

T Yoshida, K Jono and K Okonogi
Analytical Department II, Takeda Analytical Research Laboratories, Ltd., Yodogawaku, Osaka, Japan.

In vitro activities of antifungal agents, including azole compounds, against yeasts were easily determined by using RPMI-1640 agar medium and by incubating the plates in the presence of 20% CO2. The end point of inhibition was clear by this method, even in the case of azole compounds, because of the almost complete inhibition of yeast growth at high concentrations which permitted weak growth of some Candida strains by traditional methods. MICs obtained by the agar dilution method were similar to those obtained by the broth dilution method proposed by the National Committee for Clinical Laboratory Standards.


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