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Antimicrobial Agents and Chemotherapy, Aug 1997, 1812-1814, Vol 41, No. 8
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

In vitro activities of terbinafine in combination with fluconazole and itraconazole against isolates of Candida albicans with reduced susceptibility to azoles

F Barchiesi, L Falconi Di Francesco and G Scalise
Institute of Infectious Diseases and Public Health of the University of Ancona, Italy. cmalinf@popcsi.unian.it

A checkerboard microdilution method was applied to study the in vitro interaction of terbinafine with either fluconazole and itraconazole against 30 strains of Candida albicans. Synergy was observed in 40% of the terbinafine-fluconazole interactions and in 43% of the terbinafine- itraconazole interactions, while antagonism was not observed. Even when only additivity was achieved, the combinations still showed beneficial effects since at least twofold reductions in the MICs of both drugs were found in 100% of the terbinafine-fluconazole interactions and in 76% of the terbinafine-itraconazole interactions.

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