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Antimicrobial Agents and Chemotherapy, January 1998, p. 161-163, Vol. 42, No. 1
Department of Pathology, University of Iowa
College of Medicine, Iowa City, Iowa 52242
Received 1 August 1997/Returned for modification 26 September
1997/Accepted 13 October 1997
Voriconazole (formerly UK-109,496) is a new monotriazole antifungal
agent which has potent activity against Candida,
Cryptococcus, and Aspergillus species. We
investigated the in vitro activity of voriconazole compared to those of
fluconazole, itraconazole, amphotericin B, and flucytosine (5FC)
against 394 bloodstream isolates of Candida (five species)
obtained from more than 30 different medical centers. MICs of all
antifungal drugs were determined by the method recommended by the
National Committee for Clinical Laboratory Standards using RPMI 1640 test medium. Overall, voriconazole was quite active against all the
yeast isolates (MIC at which 90% of the isolates are inhibited
[MIC90],
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
In Vitro Activities of Voriconazole (UK-109,496) and Four Other
Antifungal Agents against 394 Clinical Isolates of
Candida spp.

0.5 µg/ml). Candida albicans was
the most susceptible species (MIC90, 0.06 µg/ml) and
Candida glabrata and Candida krusei were the
least (MIC90, 1 µg/ml). Voriconazole was more active than
amphotericin B and 5FC against all species except C. glabrata and was also more active than itraconazole and
fluconazole. For isolates of Candida spp. with decreased
susceptibility to fluconazole and itraconazole MICs of voriconazole
were also higher. Based on these results, voriconazole has promising
antifungal activity and further in vitro and in vivo investigations are
warranted.
*
Corresponding author. Mailing address: Medical
Microbiology Division, Department of Pathology, 606 GH, University of
Iowa College of Medicine, Iowa City, IA 52242. Phone: (319) 384-9566. Fax: (319) 356-4916. E-mail:
mpfaller{at}blue.weeg.uiowa.edu.
Present address: Microbiology Laboratory, Hospital Clinic,
University of Barcelona, 08036-Barcelona, Spain.
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