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Antimicrobial Agents and Chemotherapy, January 1998, p. 173-175, Vol. 42, No. 1
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Activity of Sanfetrinem and Affinity for the Penicillin-Binding Proteins of Streptococcus pneumoniae

Farid Sifaoui,1 Emmanuelle Varon,1 Marie-Dominique Kitzis,2 and Laurent Gutmann1,*

L.R.M.A., Université Paris VI, 75270 Paris Cedex 06,1 and Hôpital Saint-Joseph, Service de Bactériologie, 75674 Paris Cedex 14,2 France

Received 2 May 1997/Returned for modification 1 August 1997/Accepted 28 October 1997

Against penicillin-susceptible pneumococci, the activity of sanfetrinem was similar to those of penicillin, amoxicillin, cefotaxime, imipenem, and meropenem, while against penicillin-resistant strains, sanfetrinem and the carbapenems exhibited superior activity (MICs at which 90% of strains are inhibited, <= 1 µg/ml). PBP 1a in the penicillin-susceptible strain and PBP 1a and PBP 2b in the more resistant isolates seemed to be the essential penicillin-binding proteins for imipenem and sanfetrinem.

* Corresponding author. Mailing address: L.R.M.A./Université Paris VI, 15, rue de l'Ecole de Médecine, 75270 Paris Cedex 06, France. Phone: 33-1-42.34.68.63. Fax: 33-1-43.25.68.12. E-mail: gutmann{at}ccr.jussieu.fr.

Antimicrobial Agents and Chemotherapy, January 1998, p. 173-175, Vol. 42, No. 1
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Nagai, K., Davies, T. A., Jacobs, M. R., Appelbaum, P. C. (2002). Effects of Amino Acid Alterations in Penicillin-Binding Proteins (PBPs) 1a, 2b, and 2x on PBP Affinities of Penicillin, Ampicillin, Amoxicillin, Cefditoren, Cefuroxime, Cefprozil, and Cefaclor in 18 Clinical Isolates of Penicillin-Susceptible, -Intermediate, and -Resistant Pneumococci. Antimicrob. Agents Chemother. 46: 1273-1280 [Abstract] [Full Text]  


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