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Antimicrobial Agents and Chemotherapy, October 1998, p. 2745-2746, Vol. 42, No. 10
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Enhancement of Antimicrobial Activity of Neuropeptide Y by N-Terminal Truncation

Mayumi Shimizu, Yasushi Shigeri, Yoshiro Tatsu, Susumu Yoshikawa, and Noboru Yumoto*

Osaka National Research Institute, AIST, Ikeda, Osaka 563-8577, Japan

Received 13 April 1998/Returned for modification 13 May 1998/Accepted 10 July 1998

The activity of neuropeptide Y (NPY) against Candida albicans, which was revealed to be fungicidal, was enhanced significantly by the truncation of amino acid residues at the N terminus. The most active peptides (MICs, approximately 1 µM) were about 10-fold more potent than the intact NPY (MIC, approximately 10 µM). The enhancement was weakened by the replacement of the N terminus by negatively charged residues and/or acylation of the alpha -amino group. These results suggest that only the alpha -helical region of NPY is necessary for the antimicrobial activity and that the net charge of the peptide is important for the activity.

* Corresponding author. Mailing address: Osaka National Research Institute, AIST, 1-8-31 Midorigaoka, Ikeda, Osaka 563-8577, Japan. Phone: 81-727-51-9521. Fax: 81-727-51-9628. E-mail: yumoto{at}onri.go.jp.

Antimicrobial Agents and Chemotherapy, October 1998, p. 2745-2746, Vol. 42, No. 10
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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