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Antimicrobial Agents and Chemotherapy, October 1998, p. 2752-2755, Vol. 42, No. 10
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Activities of 15 Antimicrobial Agents against Clinical Isolates of South African Enterococci

M. C. Struwig,* P. L. Botha, and L. J. Chalkley

Department of Medical Microbiology, University of the Orange Free State, Bloemfontein 9300, South Africa

Received 4 February 1998/Returned for modification 31 May 1998/Accepted 17 July 1998

The activities of a panel of currently available antibiotics and the investigational agents LY 333328, linezolid, CL 331,002, CL 329,998, moxifloxacin (BAY 12-8039), trovafloxacin, and quinupristin-dalfopristin against 274 clinical isolates of enterococci were determined. No vancomycin resistance or beta -lactamase production was observed. Except for 12 isolates (all non-Enterococcus faecalis) showing reduced susceptibility to quinupristin-dalfopristin (MIC, >= 4 µg/ml), the new agents exhibited promising in vitro antienterococcal activity.

* Corresponding author. Mailing address: Department of Medical Microbiology, Internal Box G4, University of the Orange Free State, P.O. Box 339, Bloemfontein 9300, South Africa. Phone: 27 51 4053019. Fax: 27 51 4484215. E-mail: GNMBDS{at}med.uovs.ac.za.

Antimicrobial Agents and Chemotherapy, October 1998, p. 2752-2755, Vol. 42, No. 10
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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