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Antimicrobial Agents and Chemotherapy, December 1998, p. 3276-3278, Vol. 42, No. 12
Division of Microbiology,
Received 15 June 1998/Returned for modification 13 July
1998/Accepted 9 September 1998
Quinolone resistance in clinical isolates of Campylobacter
jejuni in Sweden increased more than 20-fold at the beginning of the 1990s. Resistance to 125 µg of ciprofloxacin per ml in clinical isolates was associated with chromosomal mutations in C. jejuni leading to a Thr-86-Ile substitution in the
gyrA product and a Arg-139-Gln substitution in the
parC product.
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Rapid Emergence of High-Level Resistance to
Quinolones in Campylobacter jejuni Associated with
Mutational Changes in gyrA and parC
*
Corresponding author. Mailing address: Division of
Microbiology, Department of Pharmaceutical Biosciences, P.O. Box 581, Biomedical Center, Uppsala University, S-751 23 Uppsala, Sweden. Phone:
46-18-4714500. Fax: 46-18-502790. E-mail:
ola.skold{at}farmbio.uu.se.
Antimicrobial Agents and Chemotherapy, December 1998, p. 3276-3278, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
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