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Antimicrobial Agents and Chemotherapy, December 1998, p. 3279-3281, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Activity of the New Ketolide HMR3647 in Comparison with Those of Macrolides and Pristinamycins against Enterococcus spp.

C. Torres,1,* M. Zarazaga,1 C. Tenorio,1 A. Portillo,1 Y. Saenz,1 F. Ruiz,1 and F. Baquero2

Area de Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño,1 and Servicio de Microbiología, Hospital Ramón y Cajal, Madrid,2 Spain

Received 16 March 1998/Returned for modification 28 July 1998/Accepted 16 September 1998

Ninety-four erythromycin-susceptible and 107 erythromycin-resistant enterococcal strains (MIC of >= 512 µg/ml) were inhibited by the ketolide HMR3647 at MICs of <= 0.007 to 0.06 and 0.03 to 8 µg/ml, respectively. Eighteen vanA-positive isolates and 29 high-level-penicillin-resistant isolates, all of them erythromycin resistant, were inhibited by HMR3647 at an MIC range of 0.015 to 4 µg/ml. The new ketolide has excellent activity against Enterococcus species.

* Corresponding author. Mailing address: Area de Bioquímica y Biología Molecular, Universidad de La Rioja, Avenida de la Paz, 105, 26004 Logroño, Spain. Phone: 34-941-299284. Fax: 34-941-299274. E-mail: carmen.torres{at}daa.unirioja.es.

Antimicrobial Agents and Chemotherapy, December 1998, p. 3279-3281, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Jalava, J., Kataja, J., Seppälä, H., Huovinen, P. (2001). In Vitro Activities of the Novel Ketolide Telithromycin (HMR 3647) against Erythromycin-Resistant Streptococcus Species. Antimicrob. Agents Chemother. 45: 789-793 [Abstract] [Full Text]  
  • Goldstein, E. J. C., Citron, D. M., Merriam, C. V., Warren, Y., Tyrrell, K. (1999). Activities of Telithromycin (HMR 3647, RU 66647) Compared to Those of Erythromycin, Azithromycin, Clarithromycin, Roxithromycin, and Other Antimicrobial Agents against Unusual Anaerobes. Antimicrob. Agents Chemother. 43: 2801-2805 [Abstract] [Full Text]  


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