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Antimicrobial Agents and Chemotherapy, December 1998, p. 3293-3295, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Alteration in the GyrA Subunit of DNA Gyrase and the ParC Subunit of DNA Topoisomerase IV in Quinolone-Resistant Clinical Isolates of Staphylococcus epidermidis

Zhiyu Li, Takashi Deguchi,* Mitsuru Yasuda, Takeshi Kawamura, Emiko Kanematsu, Yoshinori Nishino, Satoshi Ishihara, and Yukimichi Kawada

Department of Urology, Gifu University School of Medicine, Gifu, Japan

Received 18 June 1998/Returned for modification 13 August 1998/Accepted 9 September 1998

We examined 22 clinical isolates of Staphylococcus epidermidis to analyze the association of alterations in GyrA and ParC with fluoroquinolone resistance. The simultaneous presence of GyrA and ParC alterations was associated with a high level of fluoroquinolone resistance in the clinical isolates of S. epidermidis.

* Corresponding author. Mailing address: Department of Urology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu City, Gifu 500-8705, Japan. Phone: 81-58-265-1241. Fax: 81-58-265-9009. E-mail: deguchit{at}cc.gifu-u.ac.jp.

Antimicrobial Agents and Chemotherapy, December 1998, p. 3293-3295, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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