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Antimicrobial Agents and Chemotherapy, December 1998, p. 3296-3300, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

An ampD Gene in Pseudomonas aeruginosa Encodes a Negative Regulator of AmpC beta -Lactamase Expression

Taimour Yousef Langaee, Michèle Dargis, and Ann Huletsky*

Département de biologie médicale, Pavillon Marchand, Université Laval, Ste-Foy, Québec, Canada G1K 7P4

Received 6 April 1998/Returned for modification 28 July 1998/Accepted 23 September 1998

The ampD and ampE genes of Pseudomonas aeruginosa PAO1 were cloned and characterized. These genes are transcribed in the same orientation and form an operon. The deduced polypeptide of P. aeruginosa ampD exhibited more than 60% similarity to the AmpD proteins of enterobacteria and Haemophilus influenzae. The ampD product transcomplemented Escherichia coli ampD mutants to wild-type beta -lactamase expression.

* Corresponding author. Mailing address: Département de biologie médicale, Pavillon Marchand, Université Laval, Ste-Foy, Québec Canada G1K 7P4. Phone: (418) 656-2131, ext. 2669. Fax: (418) 656-7176. E-mail: ann.huletsky{at}rsvs.ulaval.ca.

Antimicrobial Agents and Chemotherapy, December 1998, p. 3296-3300, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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