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Antimicrobial Agents and Chemotherapy, December 1998, p. 3301-3303, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Susceptibilities of the Microsporidia Encephalitozoon cuniculi, Encephalitozoon hellem, and Encephalitozoon intestinalis to Albendazole and Its Sulfoxide and Sulfone Metabolites

Olivier Ridoux and Michel Drancourt*

Unité des Rickettsies CNRS UPRES-A 6020, Faculté de Médecine, Université de la Méditerranée, 13385 Marseille cedex 05, France

Received 24 July 1998/Returned for modification 8 September 1998/Accepted 28 September 1998

In vitro comparisons demonstrated that the efficacy of albendazole, albendazole-sulfoxide, and albendazole-sulfone against pathogenic Encephalitozoon species was proportional to the degree of oxidation at a concentration of >10-3 µg/ml. Furthermore, at a concentration of <10-2 µg/ml, benzimidazoles were more effective against Encephalitozoon cuniculi and Encephalitozoon hellem than against Encephalitozoon intestinalis.

* Corresponding author. Mailing address: Unité des Rickettsies CNRS UPRES-A 6020, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille cedex 05, France. Phone: 33(0)4 91 32 43 75. Fax: 33 (0)4 91 83 03 90. E-mail: Michel.Drancourt{at}medecine.univ-mrs.fr.

Antimicrobial Agents and Chemotherapy, December 1998, p. 3301-3303, Vol. 42, No. 12
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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