A Novel Erythromycin Resistance Methylase Gene (ermTR) in Streptococcus pyogenes

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Antimicrobial Agents and Chemotherapy, February 1998, p. 257-262, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A Novel Erythromycin Resistance Methylase Gene (ermTR) in Streptococcus pyogenes

Helena Seppälä,¹^,^* Mikael Skurnik,² Hanna Soini,³ Marilyn C. Roberts,⁴ and Pentti Huovinen¹

Antimicrobial Research Laboratory¹ and the Mycobacterial Reference Laboratory,³ National Public Health Institute, 20520 Turku, Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, 20521 Turku,² Finland, and Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98195⁴

Received 14 May 1997/Returned for modification 7 August 1997/Accepted 11 November 1997

Erythromycin resistance among streptococci is commonly due to target site modification by an rRNA-methylating enzyme, whichresults in coresistance to macrolide, lincosamide, and streptograminB antibiotics (MLS_B resistance). Genes belonging to the ermAM(ermB) gene class are the only erythromycin resistance methylase(erm) genes in Streptococcus pyogenes with MLS_B resistance thathave been sequenced so far. We identified a novel erm gene, designatedermTR, from an erythromycin-resistant clinical strain of S. pyogenes(strain A200) with an inducible type of MLS_B resistance. The nucleotidesequence of ermTR is 82.5% identical to ermA, previously found,for example, in Staphylococcus aureus and coagulase-negative staphylococci.Our finding provides the first sequence of an erm gene other thanermAM that mediates MLS_B resistance in S. pyogenes.

^* Corresponding author. Mailing address: Antimicrobial Research Laboratory, National Public Health Institute, Kiinamyllynkatu13, 20520 Turku, Finland. Phone: 358-2-2519255. Fax: 358-2-2519254.E-mail: helena.seppala{at}utu.fi.

Antimicrobial Agents and Chemotherapy, February 1998, p. 257-262, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

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