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Antimicrobial Agents and Chemotherapy, February 1998, p. 419-424, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Activities of Y-688, a New 7-Substituted Fluoroquinolone, against Anaerobic Bacteria

A. P. MacGowan,* K. E. Bowker, M. Wootton, H. A. Holt, and D. S. Reeves

Bristol Centre for Antimicrobial Research and Evaluation, Southmead Health Services NHS Trust and University of Bristol, Department of Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, United Kingdom

Received 23 July 1997/Returned for modification 20 September 1997/Accepted 20 November 1997

The in vitro activities of Y-688, a new 7-substituted fluoroquinolone derivative, against 317 nonduplicate anaerobic isolates were determined. Eighty-five percent of the Bacteroides fragilis group (n = 89) were inhibited by <= 2 mg of Y-688 per liter, while 78, 100, 89, and 98% of gram-negative bacilli (n = 135), gram-positive cocci (n = 59), and non-spore-forming (n = 58) and spore-forming (n = 51) gram-positive bacilli, respectively, were inhibited by <= 1 mg of Y-688 per liter.

* Corresponding author. Mailing address: Department of Medical Microbiology, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, United Kingdom. Phone: 0044 117 959 5652. Fax: 0044 117 959 3154. E-mail: STAFF{at}BCARE.ORG.UK.

Antimicrobial Agents and Chemotherapy, February 1998, p. 419-424, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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