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Antimicrobial Agents and Chemotherapy, February 1998, p. 456-458, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Effects of Probenecid and Cimetidine on Renal Disposition of Ofloxacin in Rats

Edward F. Foote* and Charles E. Halstenson

Drug Evaluation Unit, Division of Nephrology, Department of Medicine, Hennepin County Medical Center, and College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455

Received 28 February 1997/Returned for modification 22 July 1997/Accepted 10 November 1997

The renal handling of ofloxacin in rats which were given ofloxacin either alone or in combination with probenecid or cimetidine was studied. In the presence of cimetidine or probenecid, ofloxacin's total and renal clearances were reduced and its half-life was prolonged. This suggests that ofloxacin is secreted by both the anionic and cationic transport systems.

* Corresponding author. Present address: Department of Pharmacy Practice and Administration, College of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Rd., Piscataway, NJ 08854-8020. Phone: (732) 828-3000, ext. 2966. Fax: (732) 937-8584. E-mail: efoote{at}rci.rutgers.edu.

Antimicrobial Agents and Chemotherapy, February 1998, p. 456-458, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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