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Antimicrobial Agents and Chemotherapy, February 1998, p. 462-463, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Antimycobacterial Activity of 5-Chloropyrazinamide

Michael H. Cynamon,1,* Robert J. Speirs,1 and John T. Welch2

Veterans Affairs Medical Center, Syracuse, New York 13210,1 and Department of Chemistry, SUNY at Albany, Albany, New York 122222

Received 21 July 1997/Returned for modification 2 October 1997/Accepted 1 December 1997

5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis, Mycobacterium bovis, and several nontuberculous mycobacteria by a broth dilution method. 5-Chloropyrazinamide was more active than pyrazinamide against all organisms tested. It is likely that this agent has a different mechanism of action than pyrazinamide.

* Corresponding author. Mailing address: Department of Medicine, Veterans Affairs Medical Center, 800 Irving Ave., Syracuse, NY 13210. Phone: (315) 477-4597. Fax: (315) 424-6233. E-mail: CYNAMON.MICHAEL{at}SYRACUSE.VA.GOV.

Antimicrobial Agents and Chemotherapy, February 1998, p. 462-463, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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