This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Join-Lambert, O.
Right arrow Articles by Carbon, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Join-Lambert, O.
Right arrow Articles by Carbon, C.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, February 1998, p. 468-470, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Critical Importance of In Vivo Amoxicillin and Cefotaxime Concentrations for Synergy in Treatment of Experimental Enterococcus faecalis Endocarditis

Olivier Join-Lambert,1 Jean-Luc Mainardi,2 Catherine Cuvelier,3 Sophie Dautrey,3 Robert Farinotti,3 Bruno Fantin,1,* and Claude Carbon1

Institut National de la Santé et de la Recherche Médicale, Unité 13,1 and Service de Pharmacie Clinique et des Biomatériaux, Hôpital Bichat,3 75877 Paris Cedex 18, and Laboratoire de Microbiologie Médicale, Fondation-Hôpital Saint-Joseph, 75674 Paris Cedex 14,2 France

Received 5 May 1997/Returned for modification 6 August 1997/Accepted 27 October 1997

The synergy between amoxicillin and cefotaxime against two strains of Enterococcus faecalis (JH2-2 and 6370) in vitro and in rabbit endocarditis was investigated. In vitro synergy was obtained only when amoxicillin concentrations were below the MBC and when cefotaxime concentrations were above 1 µg/ml. No synergy was observed in vivo, because of the short period of time during which these pharmacologic requirements were achieved.

* Corresponding author. Mailing address: Unité de Médecine Interne, Hôpital Beaujon, 100, boulevard du général Leclerc, 92118 Clichy Cedex, France. Phone: 33 1 40 87 58 90. Fax: 33 1 40 87 54 95. E-mail: medecine.interne{at}bjn.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, February 1998, p. 468-470, Vol. 42, No. 2
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Baddour, L. M., Wilson, W. R., Bayer, A. S., Fowler, V. G. Jr, Bolger, A. F., Levison, M. E., Ferrieri, P., Gerber, M. A., Tani, L. Y., Gewitz, M. H., Tong, D. C., Steckelberg, J. M., Baltimore, R. S., Shulman, S. T., Burns, J. C., Falace, D. A., Newburger, J. W., Pallasch, T. J., Takahashi, M., Taubert, K. A. (2005). Infective Endocarditis: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Statement for Healthcare Professionals From the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: Endorsed by the Infectious Diseases Society of America. Circulation 111: e394-e434 [Abstract] [Full Text]  
  • Gavalda, J., Onrubia, P. L., Gomez, M. T. M., Gomis, X., Ramirez, J. L., Len, O., Rodriguez, D., Crespo, M., Ruiz, I., Pahissa, A. (2003). Efficacy of ampicillin combined with ceftriaxone and gentamicin in the treatment of experimental endocarditis due to Enterococcus faecalis with no high-level resistance to aminoglycosides. J Antimicrob Chemother 52: 514-517 [Abstract] [Full Text]  
  • Schiffelers, R. M., Storm, G., ten Kate, M. T., Stearne-Cullen, L. E. T., den Hollander, J. G., Verbrugh, H. A., Bakker-Woudenberg, I. A. J. M. (2001). In Vivo Synergistic Interaction of Liposome-Coencapsulated Gentamicin and Ceftazidime. J. Pharmacol. Exp. Ther. 298: 369-375 [Abstract] [Full Text]  
  • Lefort, A., Saleh-Mghir, A., Garry, L., Carbon, C., Fantin, B. (2000). Activity of LY333328 Combined with Gentamicin In Vitro and in Rabbit Experimental Endocarditis Due to Vancomycin-Susceptible or -Resistant Enterococcus faecalis. Antimicrob. Agents Chemother. 44: 3017-3021 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»