This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Domarle, O.
Right arrow Articles by Millet, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Domarle, O.
Right arrow Articles by Millet, P.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, March 1998, p. 540-544, Vol. 42, No. 3
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Antimalarial Activity of a New Organometallic Analog, Ferrocene-Chloroquine

O. Domarle,1,* G. Blampain,1 H. Agnaniet,2 T. Nzadiyabi,1 J. Lebibi,2 J. Brocard,3 L. Maciejewski,3 C. Biot,3 A. J. Georges,1 and P. Millet1

Centre International de Recherches Médicales de Franceville1 and Université des Sciences et Techniques du Masuku,2 Franceville, Gabon, and Université des Sciences et Technologies de Lille, Lille, France3

Received 27 May 1997/Returned for modification 23 July 1997/Accepted 17 November 1997

The in vitro activities of new organometallic chloroquine analogs, based on 4-amino-quinoleine compounds bound to a molecule of ferrocene, were evaluated against chloroquine-susceptible, chloroquine-intermediate, and chloroquine-resistant, culture-adapted Plasmodium falciparum lineages by a proliferation test. One of the ferrocene analogs totally restored the activity of chloroquine against chloroquine-resistant parasites. This compound, associated with tartaric acid for better solubility, was highly effective. The role of the ferrocene in reversing chloroquine resistance is discussed, as is its potential use for human therapy.

* Corresponding author. Mailing address: Unité de Parasitologie Médicale, CIRMF, BP 769, Franceville, Gabon. Phone: (241) 67 70 92 or 67 70 96. Fax: (241) 67 72 59. E-mail: odomarle{at}cirmfrv.fr.

Antimicrobial Agents and Chemotherapy, March 1998, p. 540-544, Vol. 42, No. 3
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Henry, M., Briolant, S., Fontaine, A., Mosnier, J., Baret, E., Amalvict, R., Fusai, T., Fraisse, L., Rogier, C., Pradines, B. (2008). In Vitro Activity of Ferroquine Is Independent of Polymorphisms in Transport Protein Genes Implicated in Quinoline Resistance in Plasmodium falciparum. Antimicrob. Agents Chemother. 52: 2755-2759 [Abstract] [Full Text]  
  • KREIDENWEISS, A., KREMSNER, P. G., DIETZ, K., MORDMULLER, B. (2006). IN VITRO ACTIVITY OF FERROQUINE (SAR97193) IS INDEPENDENT OF CHLOROQUINE RESISTANCE IN PLASMODIUM FALCIPARUM. Am J Trop Med Hyg 75: 1178-1181 [Abstract] [Full Text]  
  • Daher, W., Pelinski, L., Klieber, S., Sadoun, F., Meunier, V., Bourrie, M., Biot, C., Guillou, F., Fabre, G., Brocard, J., Fraisse, L., Maffrand, J.-P., Khalife, J., Dive, D. (2006). IN VITRO METABOLISM OF FERROQUINE (SSR97193) IN ANIMAL AND HUMAN HEPATIC MODELS AND ANTIMALARIAL ACTIVITY OF MAJOR METABOLITES ON PLASMODIUM FALCIPARUM. Drug Metab. Dispos. 34: 667-682 [Abstract] [Full Text]  
  • Atteke, C., Ndong, J. M. M., Aubouy, A., Maciejewski, L., Brocard, J., Lebibi, J., Deloron, P. (2003). In vitro susceptibility to a new antimalarial organometallic analogue, ferroquine, of Plasmodium falciparum isolates from the Haut-Ogooue region of Gabon. J Antimicrob Chemother 51: 1021-1024 [Abstract] [Full Text]  
  • Pradines, B., Fusai, T., Daries, W., Laloge, V., Rogier, C., Millet, P., Panconi, E., Kombila, M., Parzy, D. (2001). Ferrocene-chloroquine analogues as antimalarial agents: in vitro activity of ferrochloroquine against 103 Gabonese isolates of Plasmodium falciparum. J Antimicrob Chemother 48: 179-184 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»