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Antimicrobial Agents and Chemotherapy, April 1998, p. 868-872, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Survey of Resistance of Herpes Simplex Virus to Acyclovir in Northwest England

Jacqueline Christophers,1 Julie Clayton,1 John Craske,1 Rosemary Ward,1 Peter Collins,2 Martin Trowbridge,2 and Graham Darby2,*

Manchester Public Health Laboratory, Withington Hospital, Manchester, M20 2LR,1 and GlaxoWellcome Research Laboratories, Stevenage, SG1 2NY,2 United Kingdom

Received 23 July 1997/Returned for modification 3 September 1997/Accepted 20 January 1998

Acyclovir (ACV) has been used for more than 15 years in the management of herpes simplex virus (HSV) and varicella-zoster virus (VZV) disease. The present survey was undertaken to assess the level of ACV resistance in the population. More than 2,000 HSV isolates from both immunocompetent and immunocompromised patients in northwest England were collected over a 2-year period and tested for sensitivity to ACV. These studies suggested a prevalence of resistance of approximately 0.1 to 0.6% in immunocompetent individuals, with no apparent difference in prevalence between treated and untreated groups. In line with previous studies, the prevalence of resistance in treated immunocompromised individuals was approximately 6%.

* Corresponding author. Mailing address: Medicines Research Centre, GlaxoWellcome Research Laboratories, Gunnels Wood Rd., Stevenage, Hertfordshire 5G1 2NY, United Kingdom. Phone: 44-1438-764894. Fax: 44-1438-764757. E-mail: grd12649{at}ggr.co.uk.

Antimicrobial Agents and Chemotherapy, April 1998, p. 868-872, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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