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Antimicrobial Agents and Chemotherapy, April 1998, p. 942-944, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Comparative In Vitro Killing Activities of Meropenem, Imipenem, Ceftriaxone, and Ceftriaxone plus Vancomycin at Clinically Achievable Cerebrospinal Fluid Concentrations against Penicillin-Resistant Streptococcus pneumoniae Isolates from Children with Meningitis

Frederic Fitoussi,1 Catherine Doit,1 Karim Benali,2 Stephane Bonacorsi,1 Pierre Geslin,3 and Edouard Bingen1,*

Service de Microbiologie1 and Service de Biostatistiques et Informatique Médicale,2 Hôpital Robert Debré, 75019 Paris, and Centre National de Référence des Pneumocoques, Centre Hospitalier de Créteil, 94010 Créteil,3 France

Received 8 July 1997/Returned for modification 14 October 1997/Accepted 4 January 1998

The activities of meropenem, imipenem, ceftriaxone, and vancomycin were evaluated against 80 penicillin-susceptible and -resistant Streptococcus pneumoniae strains. Meropenem, imipenem, ceftriaxone, and vancomycin MICs at which 90% of the isolates are inhibited were 0.5, 0.25, 1, and 0.25 µg/ml, respectively. Against penicillin-resistant strains, the best killing activity at cerebrospinal fluid concentrations was obtained with imipenem and ceftriaxone-vancomycin. However, while the killing activity of imipenem was significantly greater than that of meropenem, no significant difference was observed between the activities of meropenem and ceftriaxone-vancomycin.

* Corresponding author. Mailing address: Service de Microbiologie, Hôpital R. Debré, 48 Bd. Sérurier, 75019 Paris, France. Phone: 33 (1) 40 03 23 40. Fax: 33 (1) 40 03 24 50. E-mail: edouard.bingen{at}rdb.ap-hop-paris.fr.

Antimicrobial Agents and Chemotherapy, April 1998, p. 942-944, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Fitoussi, F., Doit, C., Geslin, P., Bingen, E. (1999). Killing Activities of Trovafloxacin Alone and in Combination with beta -Lactam Agents, Rifampin, or Vancomycin against Streptococcus pneumoniae Isolates with Various Susceptibilities to Extended-Spectrum Cephalosporins at Concentrations Clinically Achievable in Cerebrospinal Fluid. Antimicrob. Agents Chemother. 43: 2372-2375 [Abstract] [Full Text]  
  • Kaplan, S. L., Mason, E. O. Jr. (1998). Management of Infections Due to Antibiotic-Resistant Streptococcus pneumoniae. Clin. Microbiol. Rev. 11: 628-644 [Abstract] [Full Text]  


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