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Antimicrobial Agents and Chemotherapy, April 1998, p. 956-958, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Killing of Staphylococcus aureus by C-8-Methoxy Fluoroquinolones

Xilin Zhao,1 Jian-Ying Wang,1 Chen Xu,1 Yuzhi Dong,1 Jianfeng Zhou,1 John Domagala,2 and Karl Drlica1,*

Public Health Research Institute, New York, New York 10016,1 and Parke-Davis, Pharmaceutical Research Division, Warner Lambert Company, Ann Arbor, Michigan 481052

Received 15 September 1997/Returned for modification 4 December 1997/Accepted 22 January 1998

C-8-methoxy fluoroquinolones were more lethal than C-8-bromine, C-8-ethoxy, and C-8-H derivatives for Staphylococcus aureus, especially when topoisomerase IV was resistant. The methoxy group also increased lethality against wild-type cells when protein synthesis was inhibited. These properties encourage refinement of C-8-methoxy fluoroquinolones to kill staphylococci.

* Corresponding author. Mailing address: Public Health Research Institute, 455 First Ave., New York, NY 10016. Phone: (212) 578-0830. Fax: (212) 578-0804. E-mail: drlica{at}phri.nyu.edu.

Antimicrobial Agents and Chemotherapy, April 1998, p. 956-958, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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