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Antimicrobial Agents and Chemotherapy, April 1998, p. 965-966, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Susceptibilities of Bordetella pertussis and Bordetella parapertussis to Two Ketolides (HMR 3004 and HMR 3647), Four Macrolides (Azithromycin, Clarithromycin, Erythromycin A, and Roxithromycin), and Two Ansamycins (Rifampin and Rifapentine)

Jörg E. Hoppe1,* and André Bryskier2

University Children's Hospital, D-72070 Tübingen, Germany,1 and Hoechst Marion Roussel, F-93235 Romainville Cedex, France2

Received 24 October 1997/Returned for modification 5 January 1998/Accepted 24 January 1998

When tested by agar dilution on Mueller-Hinton agar supplemented with 5% horse blood, the ketolides HMR 3004 and HMR 3647 were slightly more active (MIC at which 90% of the isolates were inhibited [MIC90], 0.03 µg/ml) against Bordetella pertussis than azithromycin, clarithromycin, erythromycin A, and roxithromycin. Azithromycin (MIC90, 0.06 µg/ml) was the most active compound against B. parapertussis. Rifampin and rifapentine were considerably less active.

* Corresponding author. Mailing address: University Children's Hospital, Rümelinstrasse 23, D-72070 Tübingen, Germany. Phone: 49/7071/2983781. Fax: 49/7071/294448.

Antimicrobial Agents and Chemotherapy, April 1998, p. 965-966, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Hewlett, E. L., Edwards, K. M. (2005). Pertussis -- Not Just for Kids. NEJM 352: 1215-1222 [Full Text]  
  • Ackermann, G., Rodloff, A. C. (2003). Drugs of the 21st century: telithromycin (HMR 3647)--the first ketolide. J Antimicrob Chemother 51: 497-511 [Abstract] [Full Text]  
  • Rastogi, N., Goh, K. S., Berchel, M., Bryskier, A. (2000). In Vitro Activities of the Ketolides Telithromycin (HMR 3647) and HMR 3004 Compared to Those of Clarithromycin against Slowly Growing Mycobacteria at pHs 6.8 and 7.4. Antimicrob. Agents Chemother. 44: 2848-2852 [Abstract] [Full Text]  


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