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Antimicrobial Agents and Chemotherapy, April 1998, p. 981-983, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Efficacy of LY333328 against Experimental Methicillin-Resistant Staphylococcus aureus Endocarditis

Glenn W. Kaatz,1,2,3,* Susan M. Seo,1,2 Jeffrey R. Aeschlimann,3,4 Heather H. Houlihan,3,4 Renee-Claude Mercier,3,4 and Michael J. Rybak1,3,4

Department of Internal Medicine, Division of Infectious Diseases, School of Medicine,1 Department of Veteran's Affairs Medical Center,2 and College of Pharmacy and Allied Health Professions,3 Wayne State University, and Anti-Infective Research Laboratory, Department of Pharmacy Services, Detroit Receiving Hospital and University Health Center,4 Detroit, Michigan 48201

Received 6 November 1997/Returned for modification 18 December 1997/Accepted 2 February 1998

The in vivo efficacy of LY333328, a new glycopeptide antibiotic, was compared with that of vancomycin by using the rabbit model of left-sided methicillin-resistant Staphylococcus aureus endocarditis. Animals received LY333328 or vancomycin (25 mg/kg of body weight every 24 or 8 h, respectively) for 4 days. These drugs were equally effective in clearing bacteremia and in reducing bacterial counts in vegetations and tissues. We conclude that in this model, LY333328 was microbiologically effective and may be a therapeutic alternative to vancomycin.

* Corresponding author. Mailing address: C3690 Detroit VA Medical Center, 4646 John R., Detroit, MI 48201. Phone: (313) 576-4487. Fax: (313) 576-1112. E-mail: gkaatz{at}juno.com.

Antimicrobial Agents and Chemotherapy, April 1998, p. 981-983, Vol. 42, No. 4
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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