This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goldstein, E. J. C.
Right arrow Articles by Merriam, C. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goldstein, E. J. C.
Right arrow Articles by Merriam, C. V.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, May 1998, p. 1127-1132, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Activities of HMR 3004 (RU 64004) and HMR 3647 (RU 66647) Compared to Those of Erythromycin, Azithromycin, Clarithromycin, Roxithromycin, and Eight Other Antimicrobial Agents against Unusual Aerobic and Anaerobic Human and Animal Bite Pathogens Isolated from Skin and Soft Tissue Infections in Humans

Ellie J. C. Goldstein,1,2,* Diane M. Citron,1 Sharon Hunt Gerardo,1 Marie Hudspeth,1 and C. Vreni Merriam1

The R. M. Alden Research Laboratory, Santa Monica-University of California, Los Angeles Medical Center, Santa Monica, California 90404,1 and University of California, Los Angeles School of Medicine, Los Angeles, California 900242

Received 7 November 1997/Returned for modification 29 January 1998/Accepted 2 March 1998

The activities of HMR 3004 and HMR 3647 and comparator agents, especially macrolides, were determined by the agar dilution method against 262 aerobic and 120 anaerobic strains isolated from skin and soft tissue infections associated with human and animal bite wounds. HMR 3004 and HMR 3647 were active against almost all aerobic and fastidious facultative isolates (MIC at which 90% of the isolates are inhibited [MIC90], <= 0.5 and 1 µg/ml, respectively) and against all anaerobes [Bacteroides tectum, Porphyromonas macacae (salivosa), Prevotella heparinolytica, Porphyromonas sp., Prevotella sp., and peptostreptococci] at <= 0.25 and <= 0.5 µg/ml, respectively, except Fusobacterium nucleatum (HMR 3004, MIC90 = 16 µg/ml; HMR 3647, MIC90 = 8 µg/ml) and other Fusobacterium species (MIC90, 1 and 2 µg/ml, respectively). In general, HMR 3004 and HMR 3647 were more active than any of the macrolides tested. Azithromycin was more active than clarithromycin against all Pasteurella species, including Pasteurella multocida subsp. multocida, Eikenella corrodens, and Fusobacterium species, while clarithromycin was more active than azithromycin against Corynebacterium species, Weeksella zoohelcum, B. tectum, and P. heparinolytica.

* Corresponding author. Mailing address: 2021 Santa Monica Blvd., Suite 640E, Santa Monica, CA 90404. Phone: (310) 315-1511. Fax: (310) 315-3662. E-mail: EJCGMD{at}aol.com.

Antimicrobial Agents and Chemotherapy, May 1998, p. 1127-1132, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Schmidt, S., Banks, R., Kumar, V., Rand, K. H., Derendorf, H. (2008). Clinical Microdialysis in Skin and Soft Tissues: An Update. J Clin Pharmacol 48: 351-364 [Abstract] [Full Text]  
  • Wagner, B. K., Martone, J. D., Conte, H., Hill, M., Kusan, K. (2006). Complications of a cat bite.. J. Am. Podiatr. Med. Assoc. 96: 455-457 [Full Text]  
  • Citron, D. M., Warren, Y. A., Fernandez, H. T., Goldstein, M. A., Tyrrell, K. L., Goldstein, E. J. C. (2005). Broth Microdilution and Disk Diffusion Tests for Susceptibility Testing of Pasteurella Species Isolated from Human Clinical Specimens. J. Clin. Microbiol. 43: 2485-2488 [Abstract] [Full Text]  
  • Shukla, S. K., Paustian, D. L., Stockwell, P. J., Morey, R. E., Jordan, J. G., Levett, P. N., Frank, D. N., Reed, K. D. (2004). Isolation of a Fastidious Bergeyella Species Associated with Cellulitis after a Cat Bite and a Phylogenetic Comparison with Bergeyella zoohelcum Strains. J. Clin. Microbiol. 42: 290-293 [Abstract] [Full Text]  
  • Tyrrell, K. L., Citron, D. M., Jenkins, J. R., Goldstein, E. J. C. (2002). Periodontal Bacteria in Rabbit Mandibular and Maxillary Abscesses. J. Clin. Microbiol. 40: 1044-1047 [Abstract] [Full Text]  
  • Wexler, H. M., Molitoris, E., Molitoris, D., Finegold, S. M. (2001). In vitro activity of telithromycin (HMR 3647) against 502 strains of anaerobic bacteria. J Antimicrob Chemother 47: 467-469 [Abstract] [Full Text]  
  • Citron, D. M., Appleman, M. D. (2001). Comparative In Vitro Activities of ABT-773 against 362 Clinical Isolates of Anaerobic Bacteria. Antimicrob. Agents Chemother. 45: 345-348 [Abstract] [Full Text]  
  • Rastogi, N., Goh, K. S., Berchel, M., Bryskier, A. (2000). In Vitro Activities of the Ketolides Telithromycin (HMR 3647) and HMR 3004 Compared to Those of Clarithromycin against Slowly Growing Mycobacteria at pHs 6.8 and 7.4. Antimicrob. Agents Chemother. 44: 2848-2852 [Abstract] [Full Text]  
  • Consigny, S., Bentoucha, A., Bonnafous, P., Grosset, J., Ji, B. (2000). Bactericidal Activities of HMR 3647, Moxifloxacin, and Rifapentine against Mycobacterium leprae in Mice. Antimicrob. Agents Chemother. 44: 2919-2921 [Abstract] [Full Text]  
  • Goldstein, E. J. C., Citron, D. M., Merriam, C. V., Warren, Y., Tyrrell, K. (2000). Comparative In Vitro Activities of ABT-773 against Aerobic and Anaerobic Pathogens Isolated from Skin and Soft-Tissue Animal and Human Bite Wound Infections. Antimicrob. Agents Chemother. 44: 2525-2529 [Abstract] [Full Text]  
  • Goldstein, E. J. C., Citron, D. M., Merriam, C. V., Warren, Y., Tyrrell, K. (1999). Activities of Telithromycin (HMR 3647, RU 66647) Compared to Those of Erythromycin, Azithromycin, Clarithromycin, Roxithromycin, and Other Antimicrobial Agents against Unusual Anaerobes. Antimicrob. Agents Chemother. 43: 2801-2805 [Abstract] [Full Text]  
  • Credito, K. L., Ednie, L. M., Jacobs, M. R., Appelbaum, P. C. (1999). Activity of Telithromycin (HMR 3647) against Anaerobic Bacteria Compared to Those of Eight Other Agents by Time-Kill Methodology. Antimicrob. Agents Chemother. 43: 2027-2031 [Abstract] [Full Text]  
  • Goldstein, E. J. C., Citron, D. M., Merriam, C. V. (1999). Linezolid Activity Compared to Those of Selected Macrolides and Other Agents against Aerobic and Anaerobic Pathogens Isolated from Soft Tissue Bite Infections in Humans. Antimicrob. Agents Chemother. 43: 1469-1474 [Abstract] [Full Text]  
  • Malathum, K., Coque, T. M., Singh, K. V., Murray, B. E. (1999). In Vitro Activities of Two Ketolides, HMR 3647 and HMR 3004, against Gram-Positive Bacteria. Antimicrob. Agents Chemother. 43: 930-936 [Abstract] [Full Text]  
  • Sáez-Nieto, J. A., Vázquez, J. A. (1999). In Vitro Activities of Ketolides HRM 3647 and HRM 3004, Levofloxacin, and Other Quinolones and Macrolides against Neisseria spp. and Moraxella catarrhalis. Antimicrob. Agents Chemother. 43: 983-984 [Abstract] [Full Text]  
  • Talan, D. A., Citron, D. M., Abrahamian, F. M., Moran, G. J., Goldstein, E. J.C., The Emergency Medicine Animal Bite Infection Study, (1999). Bacteriologic Analysis of Infected Dog and Cat Bites. NEJM 340: 85-92 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»