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Antimicrobial Agents and Chemotherapy, May 1998, p. 1245-1248, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Molecular Heterogeneity of the L-1 Metallo-beta -Lactamase Family from Stenotrophomonas maltophilia

François Sanschagrin, Julien Dufresne, and Roger C. Levesque*

Microbiologie Moléculaire et Génie des Protéines, Sciences de la Vie et de la Santé, Pavillon Charles-Eugène Marchand et Faculté de Médecine, Université Laval, Ste-Foy, Québec, Canada G1K 7P4

Received 8 July 1997/Returned for modification 21 October 1997/Accepted 10 February 1998

We have determined the nucleotide sequence of the blaS gene encoding the carbapenem-hydrolyzing L-1 beta -lactamase from Stenotrophomonas maltophilia GN12873. Analysis of the DNA and deduced amino acid sequences identified a product of 290 amino acids. Comparisons of the L-1 amino acid sequence with those of other zinc beta -lactamases showed 88.6% identity with the L-1 enzyme from S. maltophilia IID1275 and less than 20% identity with other class B metalloenzymes.

* Corresponding author. Mailing address: Microbiologie Moléculaire et Génie des Proteines, Sciences de la Vie et de la Santé, Pavillon Charles-Eugène Marchand et Faculté de Médecine, Université Laval, Ste-Foy, Québec, Canada G1K 7P4. Phone: (418) 656-3070. Fax: (418) 656-7176. E-mail: rclevesq{at}rsvs.ulaval.ca.

Antimicrobial Agents and Chemotherapy, May 1998, p. 1245-1248, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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