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Antimicrobial Agents and Chemotherapy, May 1998, p. 1245-1248, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Molecular Heterogeneity of the L-1
Metallo-
-Lactamase Family from Stenotrophomonas
maltophilia
François
Sanschagrin,
Julien
Dufresne, and
Roger C.
Levesque*
Microbiologie Moléculaire et
Génie des Protéines, Sciences de la Vie et de la
Santé, Pavillon Charles-Eugène Marchand et Faculté de
Médecine, Université Laval, Ste-Foy, Québec, Canada
G1K 7P4
Received 8 July 1997/Returned for modification 21 October
1997/Accepted 10 February 1998
We have determined the nucleotide sequence of the blaS
gene encoding the carbapenem-hydrolyzing L-1
-lactamase from
Stenotrophomonas maltophilia GN12873. Analysis of the DNA
and deduced amino acid sequences identified a product of 290 amino
acids. Comparisons of the L-1 amino acid sequence with those of other
zinc
-lactamases showed 88.6% identity with the L-1 enzyme from
S. maltophilia IID1275 and less than 20% identity with
other class B metalloenzymes.
*
Corresponding author. Mailing address: Microbiologie
Moléculaire et Génie des Proteines, Sciences de la Vie et
de la Santé, Pavillon Charles-Eugène Marchand et
Faculté de Médecine, Université Laval, Ste-Foy,
Québec, Canada G1K 7P4. Phone: (418) 656-3070. Fax: (418)
656-7176. E-mail: rclevesq{at}rsvs.ulaval.ca.
Antimicrobial Agents and Chemotherapy, May 1998, p. 1245-1248, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
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