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Antimicrobial Agents and Chemotherapy, May 1998, p. 1266-1268, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Antimicrobial Effects of Various Combinations of Penicillin and Clindamycin against Four Strains of Streptococcus pyogenes

Dennis L. Stevens,* Karl J. Madaras-Kelly, and David M. Richards

Infectious Diseases Section, VA Medical Center, Boise, and Idaho State University College of Pharmacy, Pocatello, Idaho, and University of Washington School of Medicine, Seattle, Washington

Received 28 July 1997/Returned for modification 14 December 1997/Accepted 4 March 1998

Previous studies using mouse models of Streptococcus pyogenes necrotizing fasciitis demonstrated that clindamycin had greater efficacy than penicillin. Frequently both agents are used concurrently in the treatment of severe S. pyogenes infections. This study investigated interactions between penicillin and clindamycin. E-test and broth microdilution assays suggested additivity or indifference, while timed-killing assays demonstrated concentration-dependent variable effects. Timed-kill studies utilizing clinical concentrations suggest that there is no antagonism with the combination of drugs but that the combination does not have a bactericidal advantage over either penicillin or clindamycin alone.

* Corresponding author. Mailing address: Infectious Diseases Section (Building 45), Veterans Affairs Medical Center, 500 West Fort St., Boise, ID 83702. Phone: (208) 422-1599. Fax: (208) 422-1365. E-mail: dlsteven{at}primenet.com.

Antimicrobial Agents and Chemotherapy, May 1998, p. 1266-1268, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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