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Antimicrobial Agents and Chemotherapy, May 1998, p. 1284-1287, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Antibacterial Activities and Inhibitory Effects of Sitafloxacin (DU-6859a) and Its Optical Isomers against Type II Topoisomerases

Takaaki Akasaka,* Seiko Kurosaka, Yoko Uchida, Mayumi Tanaka, Kenichi Sato, and Isao Hayakawa

New Product Research Laboratories I, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan

Received 29 December 1997/Returned for modification 12 February 1998/Accepted 12 March 1998

The in vitro inhibitory effects of sitafloxacin (DU-6859a) and its three stereoisomers on bacterial DNA gyrase from Escherichia coli, topoisomerase IV from Staphylococcus aureus, and topoisomerase II from human placenta were compared. No correlation was observed between the inhibitory activities of quinolones against bacterial type II topoisomerases and those against human topoisomerase II. Sitafloxacin showed the most potent inhibitory activities against bacterial type II topoisomerases and the lowest activity against human type II topoisomerase.

* Corresponding author. Mailing address: New Product Research Laboratories I, Daiichi Pharmaceutical Co., Ltd., 16-13, Kitakasai 1-Chome, Edogawa-ku, Tokyo 134-8630, Japan. Phone: 81-3-3680-0151. Fax: 81-3-5696-8344. E-mail: XLX06563{at}niftyserve.or.jp.

Antimicrobial Agents and Chemotherapy, May 1998, p. 1284-1287, Vol. 42, No. 5
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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