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Antimicrobial Agents and Chemotherapy, June 1998, p. 1488-1492, Vol. 42, No. 6
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Efficacies of Zinc-Finger-Active Drugs against Giardia lamblia

Theodore Nash1,* and William G. Rice2

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892,1 and Laboratory of Antiviral Drug Mechanisms, National Cancer Institute-Frederick Cancer Research and Development Center, SAIC Frederick, Frederick, Maryland 21702-12012

Received 16 September 1997/Returned for modification 9 March 1998/Accepted 20 March 1998

Twenty-nine of 34 (85%) Zn-finger-active compounds at 300 µM or less inhibited the growth of Giardia lamblia. The most active compound, disulfiram (Antabuse), was cidal at 1.23 ± 0.32 µM. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens.

* Corresponding author. Mailing address: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Rm. 81-01, Bethesda, MD 20892. Phone: (301) 496-6920. Fax: (301) 402-2689. E-mail: tnash{at}atals.niaid.nih.gov.

Antimicrobial Agents and Chemotherapy, June 1998, p. 1488-1492, Vol. 42, No. 6
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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