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Antimicrobial Agents and Chemotherapy, June 1998, p. 1499-1502, Vol. 42, No. 6
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Roxithromycin Inhibits Cytokine Production by and Neutrophil Attachment to Human Bronchial Epithelial Cells In Vitro

Shin Kawasaki,1 Hajime Takizawa,1,2,* Takayuki Ohtoshi,1 Naonobu Takeuchi,3 Tadashi Kohyama,1 Hidenori Nakamura,4 Tsuyoshi Kasama,5 Kazuo Kobayashi,6 Kazuhiko Nakahara,2 Yutaka Morita,1 and Kazuhiko Yamamoto1

Departments of Medicine and Physical Therapy,1 Laboratory Medicine,2 and Otopharyngology,3 School of Medicine, University of Tokyo, First Department of Internal Medicine, School of Medicine, Showa University,5 and National Institute of Infectious Diseases,6 Tokyo, and First Department of Internal Medicine, School of Medicine, Yamagata University, Yamagata,4 Japan

Received 30 October 1997/Returned for modification 25 February 1998/Accepted 8 April 1998

We evaluated the effect of roxithromycin on cytokine production and neutrophil attachment to human airway epithelial cells. Roxithromycin suppressed production of interleukin 8 (IL-8), IL-6, and granulocyte-macrophage colony-stimulating factor. It inhibited neutrophil adhesion to epithelial cells. Roxithromycin modulates local recruitment and activation of inflammatory cells, which may have relevance to its efficacy in airway diseases.

* Corresponding author. Mailing address: Department of Laboratory Medicine, University of Tokyo, School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan. Phone: 3-3815-5411. Fax: 3-3815-5954. E-mail: TAKIZAWA-PHY{at}h.u-tokyo.ac.jp.

Antimicrobial Agents and Chemotherapy, June 1998, p. 1499-1502, Vol. 42, No. 6
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Copyright © 1998 by the American Society for Microbiology. All rights reserved.