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Antimicrobial Agents and Chemotherapy, June 1998, p. 1512-1514, Vol. 42, No. 6
Divisions of Infectious
Diseases1 and
Clinical
Pharmacology,2
Albany Medical College,
Albany, New York 12208; Department of Ophthalmology, Albert Einstein
College of Medicine, Bronx, New York 100173;
and
Section of Infectious Diseases, University of Texas M. D. Anderson Cancer Center, Houston, Texas 770304
Received 23 May 1997/Returned for modification 17 October
1997/Accepted 19 March 1998
We conducted steady-state pharmacokinetic studies with high-dose
fluconazole with rabbits and human volunteers. We then derived mathematical equations that predict the doses of fluconazole that should be given to rabbits to produce 24-h area under the
concentration-time curve values and maximum concentrations in serum
that are similar to those measured for humans given 800 to 2,000 mg of
fluconazole per day. These equations provide a rational basis for
designing future efficacy studies with rabbits and in evaluating the
strength with which results of previously conducted studies using
rabbit infection models can be extrapolated to the clinic.
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Pharmacokinetic Studies of Fluconazole in Rabbits Characterizing
Doses Which Achieve Peak Levels in Serum and Area under the
Concentration-Time Curve Values Which Mimic Those of High-Dose
Fluconazole in Humans
and
*
Corresponding author. Mailing address: Division of
Infectious Diseases, Mail Code A-49, Albany Medical College,
Albany, NY 12208. Phone: (518) 262-5343. Fax: (518) 262-6727. E-mail:
michael_miller{at}ccgateway.amc.edu.
Present address: University of Arkansas Medical Science Center,
Little Rock, AR 72205.
Antimicrobial Agents and Chemotherapy, June 1998, p. 1512-1514, Vol. 42, No. 6
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
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