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Antimicrobial Agents and Chemotherapy, June 1998, p. 1515-1516, Vol. 42, No. 6
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Activity of a New Ketolide Antibiotic, HMR 3647, against Chlamydia pneumoniae

Patricia M. Roblin and Margaret R. Hammerschlag*

Division of Infectious Diseases, Department of Pediatrics, SUNY Health Science Center at Brooklyn, Brooklyn, New York 11203

Received 13 January 1998/Returned for modification 4 March 1998/Accepted 26 March 1998

The in vitro activities of HMR 3647, roxithromycin, erythromycin, and azithromycin against 19 strains of Chlamydia pneumoniae were tested. The MIC at which 90% of the isolates are inhibited and the minimum bactericidal concentration at which 90% of the isolates are killed of HMR 3647 were 0.25 µg/ml (range, 0.015 to 2 µg/ml). Nine recently obtained clinical isolates from children with pneumonia were more susceptible (MICs, 0.015 to 0.0625 µg/ml) than older strains that had been passaged more extensively.

* Corresponding author. Mailing address: Department of Pediatrics, Box 49, SUNY Health Science Center at Brooklyn, 450 Clarkson Ave., Brooklyn, NY 11203-2098. Phone: (718) 245-4075. Fax: (718) 245-2118. E-mail: mhammerschlag{at}pol.net.

Antimicrobial Agents and Chemotherapy, June 1998, p. 1515-1516, Vol. 42, No. 6
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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