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Antimicrobial Agents and Chemotherapy, June 1998, p. 1524-1526, Vol. 42, No. 6
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Contribution of beta -Lactamases to beta -Lactam Susceptibilities of Susceptible and Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolates

C. Segura,1,2,* M. Salvadó,1,2 I. Collado,3 J. Chaves,3 and A. Coira3

Laboratori de Referència de Catalunya1 and Departament de Genética y Microbiología,2 Universitat Autònoma de Barcelona, and Institut Municipal d'Investigació Mèdica,3 Barcelona, Spain

Received 4 September 1997/Returned for modification 18 December 1997/Accepted 24 March 1998

The beta -lactamases in 154 clinical Mycobacterium tuberculosis strains were studied. Susceptibilities to beta -lactam antibiotics, their combination with clavulanate (2:1), and two fluoroquinolones were determined in 24 M. tuberculosis strains susceptible to antimycobacterial drugs and in nine multiresistant strains. All 154 M. tuberculosis isolates showed a single chromosomal beta -lactamase pattern (pI 4.9 and 5.1). M. tuberculosis beta -lactamase hydrolyzes cefotaxime with a maximum rate of 22.5 ± 2.19 IU/liter (strain 1382). Neither amoxicillin, carbenicillin, cefotaxime, ceftriaxone, nor aztreonam was active alone. Except for aztreonam, beta -lactam combinations with clavulanate produced better antimycobacterial activity.

* Corresponding author. Mailing address: Cerdeña 257, 3o 1a, Barcelona 08013, Spain. Phone: (34)-3-2630920. Fax: (34)-3-2630671. E-mail: msalvador{at}lrc.es.

Antimicrobial Agents and Chemotherapy, June 1998, p. 1524-1526, Vol. 42, No. 6
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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