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Antimicrobial Agents and Chemotherapy, July 1998, p. 1574-1577, Vol. 42, No. 7
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Activities of Co-Amoxiclav at Concentrations Achieved in Human Serum against the Resistant Subpopulation of Heteroresistant Staphylococcus aureus: a Controlled Study with Vancomycin

J. Prieto,1 L. Aguilar,2,* M. J. Giménez,2 D. Toro,1 M. L. Gómez-Lus,1 R. Dal-Ré,2 and I. P. Balcabao1

Microbiology Department, School of Medicine, Universidad Complutense,1 and Medical Department, SmithKline Beecham Pharmaceuticals,2 Madrid, Spain

Received 3 November 1997/Returned for modification 22 March 1998/Accepted 27 April 1998

The effects of concentrations that simulated those in human serum after a single intravenous dose of amoxicillin (2 g), amoxicillin-clavulanic acid (2,000 and 200 mg, respectively), or vancomycin (500 mg), on the viability and beta -lactamase activity of two isogenic (beta -lactamase and non-beta -lactamase producer) heteroresistant Staphylococcus aureus strains were studied in an in vitro pharmacodynamic model. A reduction of >= 97% of the initial inoculum was obtained with vancomycin and amoxicillin-clavulanic acid against both strains, with respect to the total bacterial population and the oxacillin-resistant subpopulation. The same pattern was observed with amoxicillin and the beta -lactamase-negative strain. beta -Lactamase activity in the beta -lactamase-positive strain changed over time parallel to viability, decreasing with amoxicillin-clavulanic acid or vancomycin and increasing in the amoxicillin and control groups. Clavulanic acid concentrations achievable in serum that changed over time allowed amoxicillin to act against the beta -lactamase-producing methicillin-resistant S. aureus to a similar extent as vancomycin.

* Corresponding author. Mailing address: Medical Department, SmithKline Beecham Pharmaceuticals, Valle de la Fuenfría, 3, 28034 Madrid, Spain. Phone: 34-91-3345275. Fax: 34-91-3345141. E-mail: lorenzo.aguilar{at}sb.com.

Antimicrobial Agents and Chemotherapy, July 1998, p. 1574-1577, Vol. 42, No. 7
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Gonzalez, N., Aguilar, L., Alou, L., Gimenez, M.-J., Sevillano, D., Torrico, M., Cafini, F., Coronel, P., Prieto, J. (2009). Influence of different resistance traits on the competitive growth of Haemophilus influenzae in antibiotic-free medium and selection of resistant populations by different {beta}-lactams: an in vitro pharmacodynamic approach. J Antimicrob Chemother 63: 1215-1222 [Abstract] [Full Text]  
  • Torrico, M., Aguilar, L., Gonzalez, N., Gimenez, M. J., Echeverria, O., Cafini, F., Sevillano, D., Alou, L., Coronel, P., Prieto, J. (2007). Influence of TEM-1 {beta}-Lactamase on the Pharmacodynamic Activity of Simulated Total versus Free-Drug Serum Concentrations of Cefditoren (400 Milligrams) versus Amoxicillin-Clavulanic Acid (2,000/125 Milligrams) against Haemophilus influenzae Strains Exhibiting an N526K Mutation in the ftsI Gene. Antimicrob. Agents Chemother. 51: 3699-3706 [Abstract] [Full Text]  
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