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Antimicrobial Agents and Chemotherapy, July 1998, p. 1601-1604, Vol. 42, No. 7
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Antifungal Susceptibilities of Paecilomyces Species

C. Aguilar,1 I. Pujol,2 J. Sala,3 and J. Guarro1,*

Unitat de Microbiologia1 and Unitat de Bioestadística,3 Facultat de Medicina, Universitat Rovira i Virgili, and Laboratori de Microbiologia, Hospital Universitari de Sant Joan de Reus,2 43201 Reus, Tarragona, Spain

Received 18 August 1997/Returned for modification 25 February 1998/Accepted 13 April 1998

The MICs and minimum fungicidal concentrations (MFCs) of amphotericin B, miconazole, itraconazole, ketoconazole, fluconazole, and flucytosine for 52 isolates of Paecilomyces species were evaluated by the broth microdilution method, largely based on the recommendations of the National Committee for Clinical Laboratory Standards (document M27-A). The fungal isolates tested included 16 P. variotii, 11 P. lilacinus, 9 P. marquandii, 6 P. fumosoroseus, 4 P. javanicus, and 2 P. viridis isolates and 1 isolate of each of the following species: P. carneus, P. farinosus, P. fulvus, and P. niveus. The MFCs and the MICs at which 90% of isolates were inhibited (MIC90s) for the six antifungal agents were remarkably high; the MIC50s indicated that amphotericin B, miconazole, itraconazole, and ketoconazole had good activities, while fluconazole and flucytosine demonstrated poor efficacy. The ranges of the MICs were generally wider and lower than those of the MFCs. There were significant susceptibility differences among the species. All species with the exception of P. variotii were highly resistant to fluconazole and flucytosine; P. variotii was susceptible to flucytosine. Amphotericin B and the rest of the azoles showed good activity against P. variotii, while all the antifungal agents assayed showed low efficacy against P. lilacinus.

* Corresponding author. Mailing address: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Carrer Sant Llorenç, 21, 43201 Reus, Spain. Phone: 977-759359. Fax: 977-759322. E-mail: umb{at}astor.urv.es.

Antimicrobial Agents and Chemotherapy, July 1998, p. 1601-1604, Vol. 42, No. 7
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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