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Antimicrobial Agents and Chemotherapy, July 1998, p. 1845-1846, Vol. 42, No. 7
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Detection of Point Mutations in rpoB Gene of Rifampin-Resistant Rickettsia typhi

Jill Michelle Troyer,1 Suzana Radulovic,1 Siv G. E. Andersson,2 and Abdu F. Azad1,*

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland,1 and Department of Molecular Biology, Uppsala University, Biomedical Center, Uppsala, Sweden2

Received 25 November 1997/Returned for modification 20 February 1998/Accepted 6 May 1998

The rpoB gene of rifampin-resistant Rickettsia typhi (Rif mutant) and wild-type R. typhi were sequenced and compared. The Rif mutant rpoB had three nucleotide substitutions, which resulted in amino acid changes at residues 151, 201, and 271 and may be the basis for the rifampin resistance.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, University of Maryland School of Medicine, Room 13-009, Bressler Research Building, 655 West Baltimore St., Baltimore, MD 21201. Phone: (410) 706-3335. Fax: (410) 706-0282. E-mail: aazad{at}umaryland.edu.

Antimicrobial Agents and Chemotherapy, July 1998, p. 1845-1846, Vol. 42, No. 7
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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  • Drancourt, M., Raoult, D. (1999). Characterization of Mutations in the rpoB Gene in Naturally Rifampin-Resistant Rickettsia Species. Antimicrob. Agents Chemother. 43: 2400-2403 [Abstract] [Full Text]  
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