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Antimicrobial Agents and Chemotherapy, July 1998, p. 1850-1852, Vol. 42, No. 7
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Energy-Dependent Accumulation of Fluoroquinolones in Quinolone-Resistant Klebsiella pneumoniae Strains

Luis Martínez-Martínez,1,* Isabel García,1 Sofía Ballesta,1 Vicente Javier Benedí,2 Santiago Hernández-Allés,2 and Alvaro Pascual1

Department of Microbiology, School of Medicine, University of Seville, Seville,1 and Area of Microbiology, Department of Environmental Biology and IMEDEA (CSIC-UIB), University of Balearic Island, Palma de Mallorca,2 Spain

Received 29 October 1997/Returned for modification 8 January 1998/Accepted 9 March 1998

The intracellular accumulation of norfloxacin and pefloxacin in Klebsiella pneumoniae was evaluated. The roles of lipopolysaccharide, capsule, and outer membrane proteins were not important for the intrabacterial accumulation of fluoroquinolones in isogenic strains with known outer membrane alterations. In fluoroquinolone-resistant clinical isolates also expressing GyrA alterations, an active efflux leading to decreased accumulation of the drugs enhanced their resistance to these agents.

* Corresponding author. Mailing address: Department of Microbiology, School of Medicine, Apdo 914, 41080 Seville, Spain. Phone: 34-5-4557448. Fax: 34-5-4377413. E-mail: lmartin{at}cica.es.

Antimicrobial Agents and Chemotherapy, July 1998, p. 1850-1852, Vol. 42, No. 7
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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Copyright © 1998 by the American Society for Microbiology. All rights reserved.