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Antimicrobial Agents and Chemotherapy, July 1998, p. 1850-1852, Vol. 42, No. 7
Department of Microbiology,
Received 29 October 1997/Returned for modification 8 January
1998/Accepted 9 March 1998
The intracellular accumulation of norfloxacin and pefloxacin in
Klebsiella pneumoniae was evaluated. The roles of
lipopolysaccharide, capsule, and outer membrane proteins were not
important for the intrabacterial accumulation of fluoroquinolones in
isogenic strains with known outer membrane alterations. In
fluoroquinolone-resistant clinical isolates also expressing GyrA
alterations, an active efflux leading to decreased accumulation of the
drugs enhanced their resistance to these agents.
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Energy-Dependent Accumulation of Fluoroquinolones
in Quinolone-Resistant Klebsiella pneumoniae
Strains
*
Corresponding author. Mailing address: Department of
Microbiology, School of Medicine, Apdo 914, 41080 Seville, Spain.
Phone: 34-5-4557448. Fax: 34-5-4377413. E-mail:
lmartin{at}cica.es.
Antimicrobial Agents and Chemotherapy, July 1998, p. 1850-1852, Vol. 42, No. 7
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
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