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Antimicrobial Agents and Chemotherapy, August 1998, p. 2103-2105, Vol. 42, No. 8
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Identification of Novel Mutation Patterns in the parC Gene of Ciprofloxacin-Resistant Isolates of Neisseria gonorrhoeae

David L. Trees,1,* Amy L. Sandul,1 William L. Whittington,2 and Joan S. Knapp1

Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia,1 and Neisseria Reference Laboratory, Department of Medicine, University of Washington, Seattle, Washington2

Received 20 January 1998/Returned for modification 8 April 1998/Accepted 20 May 1998

Of 65 ciprofloxacin-resistant, clinical isolates of Neisseria gonorrhoeae, 5 isolates exhibited ParC mutations previously undescribed in the gonococcus. For isolates containing two ParC mutations (the Ser-87right-arrowIle and Glu-91right-arrowGly mutations and the Gly-85right-arrowCys and Arg116right-arrowLeu mutations) the MICs of ciprofloxacin (8.0 to 64.0 µg/ml) were higher than those for the isolate containing the single ParC mutation (Arg-116right-arrowLeu; MIC, 1.0 µg/ml).

* Corresponding author. Mailing address: Bacterial STD Branch, Mailstop G-39, Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333. Phone: (404) 639-2134. Fax: (404) 639-3976. E-mail: dlt1{at}cdc.gov.

Antimicrobial Agents and Chemotherapy, August 1998, p. 2103-2105, Vol. 42, No. 8
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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