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Antimicrobial Agents and Chemotherapy, August 1998, p. 2103-2105, Vol. 42, No. 8
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
Identification of Novel Mutation Patterns in the
parC Gene of Ciprofloxacin-Resistant Isolates of
Neisseria gonorrhoeae
David L.
Trees,1,*
Amy L.
Sandul,1
William L.
Whittington,2 and
Joan
S.
Knapp1
Division of AIDS, STD, and TB Laboratory
Research, National Center for Infectious Diseases, Centers for Disease
Control and Prevention, Atlanta, Georgia,1 and
Neisseria Reference Laboratory, Department of Medicine,
University of Washington, Seattle, Washington2
Received 20 January 1998/Returned for modification 8 April
1998/Accepted 20 May 1998
Of 65 ciprofloxacin-resistant, clinical isolates of Neisseria
gonorrhoeae, 5 isolates exhibited ParC mutations previously undescribed in the gonococcus. For isolates containing two ParC mutations (the Ser-87
Ile and Glu-91
Gly mutations and the
Gly-85
Cys and Arg116
Leu mutations) the MICs of ciprofloxacin (8.0 to 64.0 µg/ml) were higher than those for the isolate containing the
single ParC mutation (Arg-116
Leu; MIC, 1.0 µg/ml).
*
Corresponding author. Mailing address: Bacterial STD
Branch, Mailstop G-39, Division of AIDS, STD, and TB Laboratory
Research, National Center for Infectious Diseases, Centers for Disease
Control and Prevention, Atlanta, GA 30333. Phone: (404) 639-2134. Fax: (404) 639-3976. E-mail: dlt1{at}cdc.gov.
Antimicrobial Agents and Chemotherapy, August 1998, p. 2103-2105, Vol. 42, No. 8
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.
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