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Antimicrobial Agents and Chemotherapy, August 1998, p. 2132-2137, Vol. 42, No. 8
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Long-Term Therapy with the Guanine Nucleoside Analog Penciclovir Controls Chronic Duck Hepatitis B Virus Infection In Vivo

Enjarn Lin, Carolyn Luscombe,dagger Danni Colledge, Yan Yan Wang, and Stephen Locarnini*

Victorian Infectious Diseases Reference Laboratory, Fairfield Hospital, Fairfield, Victoria 3078, Australia

Received 3 November 1997/Returned for modification 28 January 1998/Accepted 21 May 1998

Ducks congenitally infected with duck hepatitis B virus (DHBV) were treated with the antiviral guanine nucleoside analog penciclovir for 12 or 24 weeks at a dosage of 10 mg/kg of body weight per day. By the completion of both 12 and 24 weeks of therapy, molecular hybridization studies of the liver tissue revealed that the viral DNA, RNA, and protein levels were significantly reduced compared to those in the placebo-treated controls. Penciclovir treatment for 12 or 24 weeks was not associated with any toxicity, establishing the efficacy and safety of long-term penciclovir therapy in chronic DHBV infection.

* Corresponding author. Mailing address: Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn St., North Melbourne, Victoria 3051, Australia. Phone: 61 3 9342 2614. Fax: 61 3 9342 2666. E-mail: stephenL{at}hna.ffh.vic.gov.au.

dagger Present address: Department of Molecular Genetics and Microbiology, University of New Mexico, Albuquerque, NM 87107.

Antimicrobial Agents and Chemotherapy, August 1998, p. 2132-2137, Vol. 42, No. 8
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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