This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ledee, D. R.
Right arrow Articles by Byers, T. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ledee, D. R.
Right arrow Articles by Byers, T. J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, August 1998, p. 2144-2145, Vol. 42, No. 8
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Confirmatory Evidence from 18S rRNA Gene Analysis for In Vivo Development of Propamidine Resistance in a Temporal Series of Acanthamoeba Ocular Isolates from a Patient

Dolena R. Ledee,1,dagger David V. Seal,2 and Thomas J. Byers1,*

Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210,1 and Tennent Institute of Ophthalmology, Western Infirmary, Glasgow University, Glasgow, United Kingdom2

Received 10 April 1998/Returned for modification 5 May 1998/Accepted 10 June 1998

DNA sequences of three 18S rRNA gene alleles present in trophozoites obtained before and after therapy for Acanthamoeba keratitis substantiate a previous report that the infection was due to a single Acanthamoeba strain. Thus, the possibility that propamidine resistance which developed during therapy was due to a mixed infection was ruled out.

* Corresponding author. Mailing address: Department of Molecular Genetics, The Ohio State University, 484 W. 12th Ave., Columbus, OH 43210-1292. Phone: (614) 292-5963. Fax: (614) 292-4466. E-mail: byers.2{at}osu.edu.

dagger Present address: Department of Genetics, University of Pennsylvania, Stellar Chance Labs, Philadelphia, PA 19104.

Antimicrobial Agents and Chemotherapy, August 1998, p. 2144-2145, Vol. 42, No. 8
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Krieger, J., Hett, A. K., Fuerst, P. A., Birstein, V. J., Ludwig, A. (2006). Unusual Intraindividual Variation of the Nuclear 18S rRNA Gene is Widespread Within the Acipenseridae. J Hered 97: 218-225 [Abstract] [Full Text]  
  • Ledee, D. R., Booton, G. C., Awwad, M. H., Sharma, S., Aggarwal, R. K., Niszl, I. A., Markus, M. B., Fuerst, P. A., Byers, T. J. (2003). Advantages of Using Mitochondrial 16S rDNA Sequences to Classify Clinical Isolates of Acanthamoeba. IOVS 44: 1142-1149 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»