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Antimicrobial Agents and Chemotherapy, August 1998, p. 2144-2145, Vol. 42, No. 8
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Confirmatory Evidence from 18S rRNA Gene Analysis for In Vivo Development of Propamidine Resistance in a Temporal Series of Acanthamoeba Ocular Isolates from a Patient

Dolena R. Ledee,1,dagger David V. Seal,2 and Thomas J. Byers1,*

Department of Molecular Genetics, The Ohio State University, Columbus, Ohio 43210,1 and Tennent Institute of Ophthalmology, Western Infirmary, Glasgow University, Glasgow, United Kingdom2

Received 10 April 1998/Returned for modification 5 May 1998/Accepted 10 June 1998

DNA sequences of three 18S rRNA gene alleles present in trophozoites obtained before and after therapy for Acanthamoeba keratitis substantiate a previous report that the infection was due to a single Acanthamoeba strain. Thus, the possibility that propamidine resistance which developed during therapy was due to a mixed infection was ruled out.

* Corresponding author. Mailing address: Department of Molecular Genetics, The Ohio State University, 484 W. 12th Ave., Columbus, OH 43210-1292. Phone: (614) 292-5963. Fax: (614) 292-4466. E-mail: byers.2{at}osu.edu.

dagger Present address: Department of Genetics, University of Pennsylvania, Stellar Chance Labs, Philadelphia, PA 19104.

Antimicrobial Agents and Chemotherapy, August 1998, p. 2144-2145, Vol. 42, No. 8
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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