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Antimicrobial Agents and Chemotherapy, September 1998, p. 2232-2234, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Effectiveness of Povidone-Iodine on Acanthamoeba Isolates from Human Cornea

Simonetta Gatti,1 Claudia Cevini,1 Antonella Bruno,2 Gabriella Penso,3 Paolo Rama,4 and Massimo Scaglia2,*

Laboratory of Parasitology, Virology Unit, IRCCS,1 and Infectious Diseases Research Laboratories (Laboratory of Clinical Parasitology), University-IRCCS,2 San Matteo, Pavia, Italy, and Laboratory of Biochemistry and Microbiology3 and Division of Ophthalmology,4 Venice Hospital, Venice, Italy

Received 27 October 1997/Returned for modification 4 February 1998/Accepted 30 June 1998

Acanthamoeba keratitis is a severe ocular infection secondary to accidental macro- or microscopic trauma of the cornea. Starting in 1985, a dramatic increase of this infection was recorded along with the spread of contact lens use. This protozoal disease is difficult to treat because of the scarcity of efficacious topical and systemic drugs. We evaluated the in vitro effectiveness of povidone-iodine (PVP-I [Betadine]), an agent with broad antibacterial and antiviral activity, compared to that of chlorhexidine (CXD), a cationic antiseptic, on Acanthamoeba isolates from patients with amebic keratitis. The results showed that PVP-I solution from 0.5 to 2.5% has a better antiamebic activity both on trophic and cystic stages of Acanthamoeba spp. than does CXD.

* Corresponding author. Mailing address: Infectious Diseases Research Labs (Lab. Clinical Parasitology), c/o Institute of Infectious Diseases, University-IRCCS San Matteo, 27100 Pavia, Italy. Phone: (0039) 382-502699. Fax: (0039) 382-42.33.20. E-mail: mscaglia{at}smatteo.pv.it.

Antimicrobial Agents and Chemotherapy, September 1998, p. 2232-2234, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Dini, L. A., Cockinos, C., Frean, J. A., Niszl, I. A., Markus, M. B. (2000). Unusual Case of Acanthamoeba polyphaga and Pseudomonas aeruginosa Keratitis in a Contact Lens Wearer from Gauteng, South Africa. J. Clin. Microbiol. 38: 826-829 [Abstract] [Full Text]  


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