This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jabs, D. A.
Right arrow Articles by Dunn, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jabs, D. A.
Right arrow Articles by Dunn, J. P.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, September 1998, p. 2240-2244, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Incidence of Foscarnet Resistance and Cidofovir Resistance in Patients Treated for Cytomegalovirus Retinitis

Douglas A. Jabs,1,2,* Cheryl Enger,3 Michael Forman,4 J. P. Dunn,1 for The Cytomegalovirus Retinitis, and Viral Resistance Study Group

Departments of Ophthalmology,1 Oncology,3 Pathology,4 and Medicine,2 The Johns Hopkins University School of Medicine, Baltimore, Maryland

Received 8 December 1997/Returned for modification 1 April 1998/Accepted 19 June 1998

Cytomegalovirus (CMV) retinitis is a common opportunistic infection in patients with AIDS. With long-term therapy for CMV retinitis, resistant CMV may develop. In a prospective study of 122 patients with CMV retinitis, 2.4 and 0.8% of patients had foscarnet-resistant blood culture isolates (50% inhibitory concentration [IC50], >400 µM) and urine culture isolates, respectively, at diagnosis of CMV retinitis prior to treatment, whereas 4.1 and 6.6% had cidofovir-resistant (IC50, >2 µM) blood and urine culture isolates, respectively. Patients were treated according to best medical judgement. Of 44 foscarnet-treated patients, 26% had a resistant blood or urine culture isolate by 6 months of treatment and 37% had a resistant isolate by 9 months; of 13 cidofovir-treated patients, 29% had a resistant blood or urine culture isolate by 3 months of therapy. The probabilities of developing foscarnet resistance while on foscarnet and developing cidofovir resistance while on cidofovir were not significantly different from that for developing ganciclovir resistance while on ganciclovir (odds ratios, 1.87 [P = 0.19] and 2.28 [P = 0.15], respectively).


* Corresponding author. Mailing address: The Wilmer Ophthalmological Institute, Suite 700, 550 N. Broadway, Baltimore, MD 21205. Phone: (410) 955-1966. Fax: (410) 955-0629. E-mail: dajabs{at}welchlink.welch.jhu.edu.


Antimicrobial Agents and Chemotherapy, September 1998, p. 2240-2244, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.



This article has been cited by other articles:

  • Jabs, D. A. (2008). AIDS and Ophthalmology, 2008. Arch Ophthalmol 126: 1143-1146 [Full Text]  
  • Lee, G.-C., Lee, D.-G., Choi, S.-M., Yoo, J.-H., Park, S.-H., Choi, J.-H., Min, W.-S., Cho, O.-H., Lee, C.-H., Shin, W.-S. (2005). Use of Time-Saving Flow Cytometry for Rapid Determination of Resistance of Human Cytomegalovirus to Ganciclovir. J. Clin. Microbiol. 43: 5003-5008 [Abstract] [Full Text]  
  • Gilbert, C., Boivin, G. (2005). Human Cytomegalovirus Resistance to Antiviral Drugs. Antimicrob. Agents Chemother. 49: 873-883 [Full Text]  
  • Baldanti, F., Gerna, G. (2003). Human cytomegalovirus resistance to antiviral drugs: diagnosis, monitoring and clinical impact. J Antimicrob Chemother 52: 324-330 [Abstract] [Full Text]  
  • Thomsen, D. R., Oien, N. L., Hopkins, T. A., Knechtel, M. L., Brideau, R. J., Wathen, M. W., Homa, F. L. (2003). Amino Acid Changes within Conserved Region III of the Herpes Simplex Virus and Human Cytomegalovirus DNA Polymerases Confer Resistance to 4-Oxo-Dihydroquinolines, a Novel Class of Herpesvirus Antiviral Agents. J. Virol. 77: 1868-1876 [Abstract] [Full Text]  
  • Lalezari, J. P., Aberg, J. A., Wang, L. H., Wire, M. B., Miner, R., Snowden, W., Talarico, C. L., Shaw, S., Jacobson, M. A., Drew, W. L. (2002). Phase I Dose Escalation Trial Evaluating the Pharmacokinetics, Anti-Human Cytomegalovirus (HCMV) Activity, and Safety of 1263W94 in Human Immunodeficiency Virus-Infected Men with Asymptomatic HCMV Shedding. Antimicrob. Agents Chemother. 46: 2969-2976 [Abstract] [Full Text]  
  • Koszalka, G. W., Johnson, N. W., Good, S. S., Boyd, L., Chamberlain, S. C., Townsend, L. B., Drach, J. C., Biron, K. K. (2002). Preclinical and Toxicology Studies of 1263W94, a Potent and Selective Inhibitor of Human Cytomegalovirus Replication. Antimicrob. Agents Chemother. 46: 2373-2380 [Abstract] [Full Text]  
  • Smee, D. F., Sidwell, R. W., Kefauver, D., Bray, M., Huggins, J. W. (2002). Characterization of Wild-Type and Cidofovir-Resistant Strains of Camelpox, Cowpox, Monkeypox, and Vaccinia Viruses. Antimicrob. Agents Chemother. 46: 1329-1335 [Abstract] [Full Text]  
  • Reefschlaeger, J., Bender, W., Hallenberger, S., Weber, O., Eckenberg, P., Goldmann, S., Haerter, M., Buerger, I., Trappe, J., Herrington, J. A., Haebich, D., Ruebsamen-Waigmann, H. (2001). Novel non-nucleoside inhibitors of cytomegaloviruses (BAY 38-4766): in vitro and in vivo antiviral activity and mechanism of action. J Antimicrob Chemother 48: 757-767 [Abstract] [Full Text]  
  • McSharry, J. J., McDonough, A., Olson, B., Talarico, C., Davis, M., Biron, K. K. (2001). Inhibition of Ganciclovir-Susceptible and -Resistant Human Cytomegalovirus Clinical Isolates by the Benzimidazole L-Riboside 1263W94. CVI 8: 1279-1281 [Abstract] [Full Text]  
  • McSharry, J. J., McDonough, A., Olson, B., Hallenberger, S., Reefschlaeger, J., Bender, W., Drusano, G. L. (2001). Susceptibilities of Human Cytomegalovirus Clinical Isolates to BAY38-4766, BAY43-9695, and Ganciclovir. Antimicrob. Agents Chemother. 45: 2925-2927 [Abstract] [Full Text]  
  • Romanowski, E. G., Gordon, Y. J., Araullo-Cruz, T., Yates, K. A., Kinchington, P. R. (2001). The Antiviral Resistance and Replication of Cidofovir-Resistant Adenovirus Variants in the New Zealand White Rabbit Ocular Model. IOVS 42: 1812-1815 [Abstract] [Full Text]  
  • Harmenberg, J., Brytting;, M., Jabs, D. A., Forman, M. S., Enger, C. L. (1999). Limitations of Cytomegalovirus Testing. Antimicrob. Agents Chemother. 43: 1528-1529 [Full Text]