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Antimicrobial Agents and Chemotherapy, September 1998, p. 2312-2318, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Detection of Tn917-Like Sequences within a Tn916-like Conjugative Transposon (Tn3872) in Erythromycin-Resistant Isolates of Streptococcus pneumoniae

Linda K. McDougal,1 Fred C. Tenover,1,* Linda N. Lee,2 J. Kamile Rasheed,1 Jan E. Patterson,2 James H. Jorgensen,3 and Donald J. LeBlanc4

Hospital Infections Program, Centers for Disease Control and Prevention, Atlanta, Georgia 303331; Department of Medicine2 and Department of Pathology,3 University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284; and Department of Oral Biology, Indiana University School of Dentistry, Indianapolis, Indiana 462024

Received 9 January 1998/Returned for modification 24 February 1998/Accepted 15 June 1998

A series of macrolide-lincosamide-streptogramin B (MLS)-resistant pneumococcal isolates of a variety of serotypes was examined and was found to contain Tn917-like elements by DNA-DNA hybridization. Like Tn1545, Tn917 also encodes an ermAM gene but does not mediate resistance to other antimicrobial agents. Furthermore, nucleotide sequence analyses of the DNAs flanking three of the Tn917-like elements revealed that they were inserted into orf9 of a Tn916-like element in a composite transposon-like structure (Tn3872). Other MLS-resistant strains appeared to contain Tn1545-like elements that had suffered a deletion of sequences including the aphA-3 sequences responsible for kanamycin resistance. Thus, the MLS resistance phenotype in pneumococci appears to be mediated by the ermAM present on a much wider variety of genetic elements than was previously appreciated.

* Corresponding author. Mailing address: Nosocomial Pathogens Laboratory Branch (G08), Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333. Phone: (404) 639-3246. Fax: (404) 639-1381. E-mail: FNT1{at}CDC.GOV.

Antimicrobial Agents and Chemotherapy, September 1998, p. 2312-2318, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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