This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kaiser, A. B.
Right arrow Articles by Kernodle, D. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaiser, A. B.
Right arrow Articles by Kernodle, D. S.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, September 1998, p. 2449-2451, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Synergism between Poly-(1-6)-beta -D-Glucopyranosyl-(1-3)-beta D-Glucopyranose Glucan and Cefazolin in Prophylaxis of Staphylococcal Wound Infection in a Guinea Pig Model

Allen B. Kaiser1,* and Douglas S. Kernodle1,2

Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2605,1 and the Department of Veterans Affairs Medical Center, Nashville, Tennessee 37212-26372

Received 9 February 1998/Returned for modification 6 May 1998/Accepted 10 June 1998

To determine whether the infection-preventing capability of the neutrophil-activating agent poly-(1-6)-beta -D-glucopyranosyl-(1-3)-beta -D-glucopyranose glucan (PGG-glucan) can be enhanced with antibiotic prophylaxis, we administered PGG-glucan and cefazolin, alone and in combination, to guinea pigs inoculated with isolates of staphylococci. Guinea pigs receiving both PGG-glucan and cefazolin had 50% infective doses that were 8- to 20-fold higher than those obtained with cefazolin alone and 100- to 200-fold higher than those obtained with PGG-glucan alone. PGG-glucan and cefazolin are synergistic in their ability to prevent staphylococcal wound infection.

* Corresponding author. Mailing address: Department of Medicine, D3100 MCN, Vanderbilt University Medical Center, Garland and 21st Ave. South, Nashville, TN 37232-2358. Phone: (615) 343-6821. Fax: (615) 343-7550. E-mail: allen.kaiser{at}mcmail.vanderbilt.edu.

Antimicrobial Agents and Chemotherapy, September 1998, p. 2449-2451, Vol. 42, No. 9
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»