Patterns of Macrolide Resistance Determinants among Community-Acquired Streptococcus pneumoniae Isolates over a 5-Year Period of Decreased Macrolide Susceptibility Rates

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Antimicrobial Agents and Chemotherapy, October 1999, p. 2510-2512, Vol. 43, No. 10
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Patterns of Macrolide Resistance Determinants among Community-Acquired Streptococcus pneumoniae Isolates over a 5-Year Period of Decreased Macrolide Susceptibility Rates

Philipp Oster,¹ Alessandra Zanchi,¹ Stefania Cresti,¹^,² Maria Lattanzi,¹ Francesca Montagnani,¹ Carla Cellesi,¹ and Gian Maria Rossolini²^,^*

Istituto di Clinica delle Malattie Infettive¹ and Dipartimento di Biologia Molecolare, Sezione di Microbiologia,² Università di Siena, 53100-Siena, Italy

Received 16 February 1999/Returned for modification 19 May 1999/Accepted 27 July 1999

Erythromycin resistance rates were found to be increased, from 7.1 in 1993 to 32.8% in 1997, among community-acquired Streptococcuspneumoniae isolates from the Siena area of central Italy. Mostof the erythromycin-resistant isolates carried ermAM determinantsand were also resistant to josamycin and clindamycin, whereasa minority (5.8%) carried mefA determinants and remained susceptibleto the latterdrugs.

^* Corresponding author. Mailing address: Dipartimento di Biologia Molecolare, Sezione di Microbiologia, Università di Siena,Via Laterina, 8, 53100 Siena, Italy. Phone: 39 0577 233455. Fax:39 0577 233325. E-mail: rossolini{at}unisi.it.

Antimicrobial Agents and Chemotherapy, October 1999, p. 2510-2512, Vol. 43, No. 10
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

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