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Antimicrobial Agents and Chemotherapy, October 1999, p. 2513-2516, Vol. 43, No. 10
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Association of Alterations in ParC and GyrA Proteins with Resistance of Clinical Isolates of Enterococcus faecium to Nine Different Fluoroquinolones

Sylvain Brisse,1,* Ad C. Fluit,1 Ulrich Wagner,2 Peter Heisig,3 Dana Milatovic,1 Jan Verhoef,1 Sybille Scheuring,2 Karl Köhrer,2 and Franz-Josef Schmitz1,2

Eijkman-Winkler Institute, Utrecht University, 3584 CX, Utrecht, The Netherlands,1 and Institute for Medical Microbiology and Virology, University Hospital Düsseldorf, D-40225 Düsseldorf,2 and Institute for Pharmaceutical Microbiology, University of Bonn, Bonn,3 Germany

Received 30 March 1999/Returned for modification 28 June 1999/Accepted 27 July 1999

The parC and gyrA genes of 73 ciprofloxacin-resistant and 6 ciprofloxacin-susceptible Enterococcus faecium clinical isolates were partly sequenced. Alterations in ParC and GyrA, possibly in combination with other resistance mechanisms, severely restricted the in vitro activities of the nine quinolones tested. For all isolates, clinafloxacin and sitafloxacin showed the best activities.

* Corresponding author. Mailing address: Eijkman-Winkler Institute, Utrecht University, AZU G04.614, Heidelberglaan 100, 3585 CX, Utrecht, The Netherlands. Phone: 31 30 250-7625. Fax: 31 30 254-1770. E-mail: sbrisse{at}lab.azu.nl.

Antimicrobial Agents and Chemotherapy, October 1999, p. 2513-2516, Vol. 43, No. 10
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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