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Antimicrobial Agents and Chemotherapy, October 1999, p. 2528-2533, Vol. 43, No. 10
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Anti-Kaposi's Sarcoma and Antiangiogenic Activities of Sulfated Dextrins

Mark Thornton,1 Laura Barkley,1 Justin C. Mason,2 and Sunil Shaunak1,*

Departments of Infectious Diseases1 and Cardiovascular Medicine,2 Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom

Received 2 December 1998/Returned for modification 24 May 1999/Accepted 15 July 1999

Delivery of the sulfated polysaccharide dextrin 2-sulfate by the intraperitoneal route to the lymphatic circulation resulted in a clinically significant improvement in Kaposi's sarcoma in three patients. Our in vitro studies show that although sulfated dextrins do not interfere with the growth of isolated human umbilical vein endothelial cells, they do inhibit the morphological differentiation of endothelial cells into tubes as well as reduce new vessel formation in a placental angiogenesis assay. The antiangiogenic effect of dextrin 6-sulfate is greater than that of dextrin 2-sulfate and is independent of their anti-human immunodeficiency virus type 1 activities.

* Corresponding author. Mailing address: Department of Infectious Diseases, Division of Investigative Science, Imperial College School of Medicine, Hammersmith Hospital, Ducane Road, London W12 ONN, United Kingdom. Phone: 44 (0)208 383 3222. Fax: 44 (0)208 383 3394. E-mail: s.shaunak{at}ic.ac.uk.

Antimicrobial Agents and Chemotherapy, October 1999, p. 2528-2533, Vol. 43, No. 10
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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