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Antimicrobial Agents and Chemotherapy, October 1999, p. 2555-2558, Vol. 43, No. 10
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Potentiation of Artemisinin Activity against Chloroquine-Resistant Plasmodium falciparum Strains by Using Heme Models

Françoise Benoit-Vical,1 Anne Robert,2 and Bernard Meunier2,*

Laboratoire d'Immunologie et Parasitologie, UFR Sciences Pharmaceutiques, 34060 Montpellier Cedex 2,1 and Laboratoire de Chimie de Coordination du CNRS, 31077 Toulouse Cedex 4,2 France

Received 26 April 1999/Returned for modification 13 July 1999/Accepted 2 August 1999

The influence of different metalloporphyrin derivatives on the antimalarial activity of artemisinin was studied with two chloroquine-resistant strains of Plasmodium falciparum (FcB1-Colombia and FcM29-Cameroon) cultured in human erythrocytes. This potentiation study indicates that the manganese complex of meso-tetrakis(4-sulfonatophenyl)porphyrin has a significant synergistic effect on the activity of artemisinin against both Plasmodium strains.

* Corresponding author. Mailing address: Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, 31077 Toulouse Cedex 4, France. Phone: 33 5 61 33 31 46. Fax: 33 5 61 55 30 03. E-mail: bmeunier{at}lcc-toulouse.fr.

Antimicrobial Agents and Chemotherapy, October 1999, p. 2555-2558, Vol. 43, No. 10
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Benoit-Vical, F., Lelievre, J., Berry, A., Deymier, C., Dechy-Cabaret, O., Cazelles, J., Loup, C., Robert, A., Magnaval, J.-F., Meunier, B. (2007). Trioxaquines Are New Antimalarial Agents Active on All Erythrocytic Forms, Including Gametocytes. Antimicrob. Agents Chemother. 51: 1463-1472 [Abstract] [Full Text]  
  • Benoit-Vical, F., Robert, A., Meunier, B. (2000). In Vitro and In Vivo Potentiation of Artemisinin and Synthetic Endoperoxide Antimalarial Drugs by Metalloporphyrins. Antimicrob. Agents Chemother. 44: 2836-2841 [Abstract] [Full Text]  


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