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Antimicrobial Agents and Chemotherapy, November 1999, p. 2776-2779, Vol. 43, No. 11
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Synergy Testing of Vancomycin-Resistant Enterococcus faecium against Quinupristin-Dalfopristin in Combination with Other Antimicrobial Agents

S. O. Matsumura,1 L. Louie,1 M. Louie,1,2 and A. E. Simor1,2,*

Department of Microbiology, SD Laboratory Services, Sunnybrook and Women's College Health Sciences Centre, North York,1 and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto,2 Ontario, Canada

Received 11 February 1999/Returned for modification 31 May 1999/Accepted 29 August 1999

Using checkerboard and time-kill assays, we evaluated the in vitro activity of quinupristin-dalfopristin (RP 59500) alone and in combination with five other antimicrobial agents against 12 clinical strains of vancomycin-resistant Enterococcus faecium (VREF). In time-kill studies, six VREF strains exhibited synergism with the combination of quinupristin-dalfopristin and doxycycline and three exhibited synergism with quinupristin-dalfopristin plus ampicillin-sulbactam. Combinations of quinupristin-dalfopristin with these and other agents warrant further clinical evaluation for the treatment of serious VREF infections.

* Corresponding author. Mailing address: Department of Microbiology, Sunnybrook and Women's College Health Sciences Centre, B121-2075 Bayview Ave., North York, Ontario, Canada M4N 3M5. Phone: (416) 480-4549. Fax: (416) 480-6845. E-mail: andrew.simor{at}sunnybrook.on.ca.

Antimicrobial Agents and Chemotherapy, November 1999, p. 2776-2779, Vol. 43, No. 11
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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