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Antimicrobial Agents and Chemotherapy, November 1999, p. 2783-2786, Vol. 43, No. 11
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

In Vitro Activities of Gatifloxacin, Two Other Quinolones, and Five Nonquinolone Antimicrobials against Obligately Anaerobic Bacteria

Reiner Schaumann,* Grit Ackermann, Baerbel Pless, Marina C. Claros, and Arne C. Rodloff

Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany

Received 26 October 1998/Returned for modification 26 March 1999/Accepted 18 August 1999

The activity of the new fluoroquinolone gatifloxacin was compared with those of other quinolones and antimicrobial agents of other classes against 294 anaerobes by the broth microdilution technique. For all strains tested, gatifloxacin MICs at which 50 and 90% of the isolates were inhibited were 0.5 and 2 mg/liter, respectively, and were 3 to 4 dilution steps lower than, e.g., ciprofloxacin.

* Corresponding author. Mailing address: Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Liebigstr. 24, D-04103 Leipzig, Germany. Phone: (0341) 97 15 200. Fax: (0341) 97 15 209. E-mail: schaur{at}medizin.uni-leipzig.de.

Antimicrobial Agents and Chemotherapy, November 1999, p. 2783-2786, Vol. 43, No. 11
0066-4804/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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